CBD for PCOS: Hormones, Pain, and Mood Support | PureCraft CBD

Important Medical Notice  |  This article is for informational and educational purposes only and does not constitute medical advice. PCOS is a complex hormonal condition requiring physician evaluation and ongoing management. CBD is not an FDA-approved treatment for PCOS and does not regulate hormones, menstrual cycles, or fertility. People with PCOS on Metformin, oral contraceptives, spironolactone, or other medications should disclose CBD use to their physician before starting, due to potential CYP450 enzyme interactions. For questions about PCOS and fertility, consult a reproductive endocrinologist. PureCraft CBD products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.

 

Understanding PCOS — and Where CBD Fits

Polycystic ovary syndrome is the most common endocrine disorder in women of reproductive age, affecting 8–13% of the global female population across all ethnicities. Despite its name, PCOS is not primarily a condition of cysts — it is a complex, multi-system hormonal and metabolic disorder characterized by three core features: androgen excess (elevated testosterone and related hormones), ovulatory dysfunction (irregular or absent periods), and polycystic-appearing ovaries on ultrasound.

 

PCOS produces a constellation of symptoms that span pain, hormonal changes, metabolic dysregulation, mood disorders, skin changes, and sleep disruption — affecting quality of life in ways that go well beyond reproductive function. This multidimensional symptom profile is exactly the kind of complex picture where a supplement with multiple mechanisms (CBD) has the most opportunity to contribute meaningful support.

 

The most important framing for this guide: CBD is not a PCOS hormone treatment. It does not regulate the LH surges that drive androgen overproduction. It does not reduce testosterone levels or restore ovulatory regularity. What CBD does address — through well-characterized mechanisms — is the anxiety, pain, inflammation, sleep disruption, and skin symptoms that PCOS produces in the majority of affected people.

 

This post is a supporting post in PureCraft's Conditions cluster. For the women's health cluster posts that cover overlapping hormonal pain conditions, see:CBD for PMS |CBD for Period Pain |CBD for Endometriosis |CBD and Hormones.

 

The Biology of PCOS: Why It Affects So Many Systems

Understanding why PCOS produces such a wide range of symptoms requires a brief look at its core hormonal mechanism. In PCOS, the normal LH pulse pattern from the pituitary gland becomes dysregulated — LH pulses are more frequent and of higher amplitude, creating a sustained stimulus to the theca cells of the ovary to produce androgens. Normally, granulosa cells convert theca-produced androgens to estrogen under FSH stimulation. In PCOS, FSH signaling is relatively impaired compared to LH, so the conversion is incomplete and androgens accumulate.

 

The resulting hyperandrogenism drives the visible symptoms (acne, hirsutism, scalp hair thinning) and disrupts ovulation, but it also connects to the metabolic dimension: insulin resistance — present in 70–80% of PCOS patients regardless of BMI — amplifies androgen production by stimulating theca cells directly and by reducing sex hormone-binding globulin (SHBG), which increases the proportion of free (bioactive) testosterone in circulation. Chronic low-grade inflammation, the HPA axis, and the ECS are all interwoven into this picture — creating the multi-system syndrome that makes PCOS so complex to manage and so responsive to multi-mechanism approaches.

 

The ECS in PCOS: A Specific Connection

The endocannabinoid system plays a direct role in female reproductive physiology — CB1 and CB2 receptors are expressed in the ovary, uterus, fallopian tubes, and hypothalamus-pituitary-ovarian (HPO) axis. Endocannabinoid tone regulates ovarian follicle development, oocyte maturation, and the HPO axis hormone pulsatility. A2018 review in Molecular Human Reproduction found evidence that ECS dysregulation contributes to the ovulatory dysfunction of PCOS — elevated FAAH activity in ovarian tissue was associated with impaired follicle maturation, and anandamide levels were reduced in the follicular fluid of PCOS patients compared to non-PCOS controls. For the foundational ECS science, seeWhat Is the Endocannabinoid System?.

 

This ECS-PCOS connection is an emerging area of research — not yet at the level of established clinical guidance — but it provides a mechanistic rationale for why CBD's FAAH inhibition and ECS tone support may have broader effects on PCOS physiology than just symptom management.

 

PCOS Symptoms and CBD's Role — What Helps and What Doesn't

 

 

PCOS Symptom / Feature	Primary Mechanism	CBD's Relevant Action	Evidence Level	Realistic Expectation
Chronic pelvic and period pain (dysmenorrhea, ovarian cysts)	Prostaglandin-driven uterine cramping; ovarian cyst tension pain; possible endometriosis co-occurrence (30% of PCOS patients); pelvic floor hypertonicity from chronic pain	CB1/CB2 receptors expressed in uterine and ovarian tissue; TRPV1 desensitization for pelvic nociception; 5-HT1A central sensitization modulation for chronic pelvic pain; anti-inflammatory CB2 for cyst-adjacent tissue inflammation	Moderate — CB1/CB2 in reproductive tissue well-documented; PCOS-specific CBD pain trials absent; evidence transfers from period pain and pelvic inflammatory research	Pain reduction comparable to what CBD provides for other inflammatory pain conditions; not equivalent to NSAID acute relief but meaningful cumulative reduction over 4–6 weeks
Hyperandrogenism (elevated testosterone, DHEA-S; hirsutism, acne)	LH surge dysregulation stimulating theca cells to overproduce androgens (testosterone, androstenedione); impaired follicle maturation leaving excess androgen-producing theca cells; insulin resistance amplifies androgen production	CBD's indirect androgen pathway via ECS modulation is modest and not well-characterized for androgen reduction specifically; the sebostatic effect (CBD reduces sebum via sebaceous gland CB2) addresses acne; hair follicle CB1 modulation may partially affect follicular androgen sensitivity	Limited for androgens directly — CBD does not meaningfully reduce testosterone production; the sebostatic benefit for PCOS acne is the most applicable finding	CBD's primary androgenic symptom benefit is via the sebostatic mechanism for acne — not hormone-level reduction; hirsutism requires physician-directed treatment (spironolactone, oral contraceptives)
Insulin resistance (70–80% of PCOS patients)	Insulin receptor post-receptor signaling defect independent of obesity; hyperinsulinemia drives LH dysregulation and androgen overproduction; impairs SHBG production, increasing free testosterone	CBD's insulin sensitivity effects are preclinically documented but human evidence for PCOS specifically is absent; ECS overactivation in adipose tissue contributes to insulin resistance and CBD's ECS modulation may partially restore insulin sensitivity; anti-neuroinflammatory action may reduce the chronic inflammation component of insulin resistance	Emerging — preclinical insulin sensitivity data; no PCOS-specific insulin resistance CBD RCT; Metformin remains the primary evidence-based intervention	Modest potential contribution to insulin sensitivity as adjunct to diet, exercise, and physician-directed treatment; not a substitute for Metformin or lifestyle intervention
Anxiety and mood disorders (prevalent in PCOS — 34–57% anxiety rate)	HPA axis dysregulation from chronic hormonal stress; cortisol elevation amplified by insulin resistance; progesterone metabolite (allopregnanolone) dysregulation affecting GABA signaling; social/psychological burden of PCOS symptoms	CBD's 5-HT1A anxiolytic mechanism is the most directly applicable PCOS benefit; HPA cortisol modulation addresses the HPA dysregulation that PCOS amplifies; anandamide preservation supports mood stability	Strong — CBD's anxiety mechanisms are the same regardless of etiology; the anxiety in PCOS responds to the same CBD mechanisms established across the anxiety literature	CBD's most accessible PCOS benefit — the anxiety and HPA dysregulation respond to CBD within the same 4–8 week timeline established for general anxiety; see CBD for Anxiety Pillar
Sleep disruption	HPA dysregulation delaying sleep onset; anxiety-driven hyperarousal; obstructive sleep apnea risk elevated in PCOS (androgen-driven upper airway changes); pain waking from pelvic discomfort	CBD+CBN Sleep Gummies address all components except structural sleep apnea: HPA modulation for cortisol-driven insomnia, CBN for physiological arousal reduction, physiological melatonin for circadian timing	Strong — CBD's sleep mechanisms are well-established regardless of cause; sleep apnea requires separate medical management	Meaningful sleep improvement within 2–3 weeks using the morning oil + bedtime Sleep Gummies protocol; sleep apnea component requires physician evaluation
Chronic inflammation (PCOS as pro-inflammatory state)	Elevated CRP, TNF-α, IL-6, IL-18 in PCOS regardless of BMI; chronic low-grade inflammation driving androgen production, insulin resistance, and cardiovascular risk; oxidative stress amplifying inflammatory signaling	CB2 anti-inflammatory and anti-neuroinflammatory mechanisms reduce circulating cytokine production; FAAH inhibition preserving anandamide's systemic anti-inflammatory signaling; anti-oxidant Nrf2 activation	Moderate — CBD's systemic anti-inflammatory effects are well-established; PCOS-specific cytokine data for CBD is preclinical but consistent with CBD's general anti-inflammatory profile	Meaningful reduction in systemic inflammatory markers over 6–8 weeks of consistent use; most relevant for cardiovascular risk reduction in PCOS long-term
Weight management challenges (visceral adiposity, appetite dysregulation)	Insulin resistance promoting fat storage; hyperinsulinemia driving appetite; ECS overactivation in adipose tissue (CB1 in fat cells increases lipogenesis and appetite via endocannabinoid tone in reward circuits)	CBD's ECS modulation paradoxically opposes CB1 overactivation in adipose tissue — preclinical data shows CBD reduces lipogenesis in fat cells and may improve adipokine balance; not a weight loss drug but may partially address the ECS-adipose dysregulation in PCOS	Emerging — preclinical adipose data; no PCOS-specific weight management CBD RCT; lifestyle intervention (caloric deficit, resistance training) remains primary	Modest potential support for the ECS-metabolic component; not a substitute for dietary and exercise intervention

 

 

The pattern in this table:CBD's strongest PCOS applications are anxiety/mood (strongest evidence — same mechanisms as general anxiety), sleep disruption (strong — same sleep mechanisms apply regardless of cause), and pain (moderate — CB1/CB2 in reproductive tissue and TRPV1 mechanisms). CBD's weakest PCOS applications are direct androgen reduction (minimal — CBD does not meaningfully lower testosterone) and insulin resistance (emerging, not established). The most impactful CBD contribution to PCOS quality of life is through the anxiety, sleep, and pain dimensions — which are often more functionally impairing than the hormonal features themselves.

 

PCOS Pain: CBD's Most Immediately Accessible Benefit

PCOS-related pain — pelvic pain, dysmenorrhea, and cyst-related discomfort — affects a significant proportion of people with PCOS and is poorly addressed by standard PCOS management (which focuses on hormonal and metabolic intervention rather than analgesia). The CB1 and CB2 receptors are expressed in uterine smooth muscle, ovarian tissue, and pelvic peritoneum — all relevant to PCOS pain. CBD's anti-inflammatory CB2 mechanism reduces the prostaglandin-amplifying inflammatory signaling in pelvic tissue; TRPV1 desensitization reduces the burning, cramping quality of uterine nociception; and 5-HT1A central sensitization modulation addresses the central pain amplification that develops when pelvic pain becomes chronic. For the full period pain and pelvic mechanism picture, seeCBD for Period Pain.

 

For PCOS pelvic pain: systemicCBD Oil (20–30mg morning, with an optional additional dose 60–90 minutes before anticipated pain-peak timing) is the primary approach.CBD Topical applied to the lower abdomen can provide additional local TRPV1 desensitization for surface-accessible pain. The combination is most effective for acute pain management alongside the chronic anti-inflammatory protocol.

 

PCOS Anxiety and Depression: CBD's Most Evidence-Supported PCOS Application

Anxiety disorders affect 34–57% of people with PCOS — a rate significantly higher than the general population — driven by a combination of HPA axis dysregulation from chronic hormonal stress, cortisol elevation amplified by insulin resistance, allopregnanolone (a progesterone metabolite with GABA-modulating properties) dysregulation, and the psychological burden of managing a chronic condition affecting appearance, fertility, and metabolic health. Depression affects approximately 28% of PCOS patients, nearly double the general population rate. This anxiety-depression comorbidity in PCOS is where CBD's strongest mechanisms are most directly applicable. For the full anxiety mechanism science, seeCBD for Anxiety: The Complete Guide, and for the depression overlap, seeCBD for Depression: What the Science Actually Says.

 

The specific PCOS-anxiety connection worth noting: the HPA dysregulation in PCOS is bidirectional. PCOS causes HPA dysregulation (elevated cortisol from chronic hormonal stress); HPA dysregulation worsens PCOS symptoms (cortisol elevates androgen production through adrenal DHEA-S and amplifies insulin resistance). CBD's HPA modulation interrupts this bidirectional cycle — not by directly regulating PCOS hormones, but by reducing the cortisol burden that amplifies PCOS's hormonal and metabolic effects. This is a meaningful indirect contribution to PCOS management even without direct androgenic effects.

 

PCOS Skin: Acne, Hirsutism, and CBD's Sebostatic Mechanism

Androgen-driven acne is one of the most visible and psychologically impactful PCOS symptoms — appearing on the face, chest, and back in patterns typical of hormonal acne (jawline, lower face). CBD's sebostatic mechanism — the CB2-mediated reduction in sebum production from sebaceous glands documented in the2014 Journal of Clinical Investigation study — directly addresses the sebum overproduction that feeds androgen-driven acne. For PCOS acne specifically,CBD Topical applied to affected areas as part of a daily skincare routine reduces sebum and local sebaceous inflammation. The full skin mechanism is covered inCBD for Eczema and Skin Inflammation.

 

Important clarity on hirsutism:CBD's sebostatic and anti-androgenic effects on sebaceous glands do not extend to meaningful reduction of body hair growth from hyperandrogenism. Hirsutism requires physician-directed management — typically spironolactone (anti-androgen), oral contraceptives (reducing free testosterone via SHBG increase), or procedural approaches (laser hair removal). CBD does not reduce testosterone levels and does not address the androgen receptor sensitivity that drives hirsutism.

 

CBD and PCOS Medications: What You Need to Know

 

 

Treatment	Primary Mechanism	Evidence for PCOS	Key Interactions with CBD
Metformin (biguanide — first-line for PCOS metabolic)	Reduces hepatic glucose production; improves peripheral insulin sensitivity; reduces hyperinsulinemia and thus reduces LH-driven androgen overproduction; indirect androgen reduction via insulin sensitization	Strong — reduces androgen levels, improves menstrual regularity, reduces cardiovascular risk markers; well-established in PCOS guidelines	CYP2C8 involvement is minor; no significant CBD-Metformin pharmacokinetic interaction documented; blood glucose monitoring still advisable when adding CBD; disclose to prescribing physician
Combined oral contraceptives (for cycle regulation and androgen suppression)	Suppress LH surge reducing theca cell androgen production; progestin component provides menstrual regulation; ethinylestradiol increases SHBG binding free testosterone	Strong for symptom management — hirsutism, acne, cycle regulation; does not address underlying metabolic PCOS	Estrogen-containing OCP metabolism via CYP3A4 — CBD's CYP3A4 inhibition may modestly increase ethinylestradiol levels; physician disclosure required; not expected to be clinically significant at typical CBD doses but warrants monitoring
Spironolactone (anti-androgen — for hirsutism/acne)	Aldosterone antagonist with anti-androgenic properties — blocks androgen receptor at hair follicle and sebaceous gland; reduces hirsutism and acne	Moderate-strong for hirsutism and androgen-driven acne in PCOS	CBD may modestly increase spironolactone levels via CYP2C8 inhibition; both have mild blood pressure-lowering effects; physician disclosure required; monitor blood pressure
Inositol (myo-inositol / D-chiro-inositol)	Second messenger in FSH and insulin signaling pathways; improves insulin sensitivity and FSH response; reduces hyperinsulinemia and androgen production through different pathway than Metformin	Moderate — multiple RCTs showing improvement in menstrual regularity, androgen levels, and insulin sensitivity; well-tolerated and available without prescription	No significant CBD-inositol interaction; complementary mechanisms (inositol: insulin signaling; CBD: ECS/inflammation/HPA); can be combined safely
Spearmint tea (herbal anti-androgen)	Spearmint has demonstrated anti-androgenic properties in two small RCTs — mechanism may involve reduction in free testosterone via SHBG modulation or direct anti-androgenic effect at the follicular level	Limited but specific — 2010 Phytotherapy Research RCT showed reduction in free androgen index with spearmint tea twice daily; effect size modest	No known CBD-spearmint interaction; complementary approaches addressing different PCOS dimensions
CBD (PureCraft Nano Oil)	5-HT1A anxiolytic for PCOS anxiety; HPA modulation for cortisol component; CB2 systemic anti-inflammatory; sebostatic for PCOS acne; sleep improvement via morning oil + Sleep Gummies protocol	Emerging for PCOS directly — no PCOS-specific CBD RCT; strong evidence for individual symptom targets (anxiety, sleep, inflammation, acne)	Foundation for symptom management alongside physician-directed PCOS treatment

 

 

The Oral Contraceptive Interaction: What Matters

Ethinylestradiol (the estrogen component of most combined oral contraceptives) is metabolized by CYP3A4. CBD inhibits CYP3A4 — this could theoretically increase ethinylestradiol exposure. In practice, at typical supplement CBD doses (20–40mg of nano-optimized CBD), the magnitude of this interaction is unlikely to be clinically significant for most people, but physician disclosure is appropriate. If you are on oral contraceptives and start CBD, inform your prescribing physician and monitor for any change in cycle pattern or side effect profile. See the full interaction guide:CBD and Drug Interactions: The CYP450 Guide.

 

CBD and PCOS Fertility: The Critical Caveat

This section exists because fertility is one of the primary concerns for many people with PCOS — and it requires complete transparency. The research on CBD and fertility is insufficient to support recommendations for people actively trying to conceive or undergoing fertility treatment.

 

 

CBD Dosage for PCOS: A Symptom-Specific Protocol

All doses referencePureCraft Nano CBD Oil at approximately 90% bioavailability.

 

 

Frequently Asked Questions

 

Can CBD help PCOS symptoms?

Yes — for the symptom dimensions that CBD's mechanisms directly address: anxiety and mood (34–57% of PCOS patients have anxiety; CBD's 5-HT1A and HPA mechanisms are well-established), pelvic pain (CB1/CB2 in reproductive tissue; TRPV1 desensitization for cramping and cyst pain), chronic inflammation (CB2 anti-inflammatory reduces the pro-inflammatory state characteristic of PCOS), sleep disruption (CBD+CBN Sleep Gummies address PCOS-driven insomnia), and androgenic acne (sebostatic CB2 mechanism in sebaceous glands). CBD's contribution to PCOS is as a symptom management supplement — it does not regulate hormones, restore ovulatory function, or reduce androgen levels meaningfully. The most impactful CBD contribution to PCOS quality of life is through the anxiety, sleep, and pain dimensions, which collectively determine daily functional wellbeing more than the hormonal features in many people's experience.

 

Does CBD affect PCOS hormones?

CBD does not meaningfully reduce testosterone, LH, or other androgens elevated in PCOS. The ECS plays a modulatory role in the HPO axis, and FAAH inhibition in ovarian tissue may theoretically influence follicular dynamics — but this is preclinical and speculative at the level of clinical guidance. CBD's indirect effects on the hormonal picture of PCOS operate through the HPA axis: reducing chronic cortisol load reduces the adrenal DHEA-S component of androgen overproduction and may modestly improve the hormonal environment, but this is a minor and indirect effect compared to what Metformin, oral contraceptives, or spironolactone achieve. People with PCOS seeking hormonal management should work with their physician; CBD is not a hormonal intervention.

 

CBD for PCOS pain vs period pain — what's different?

The underlying pain mechanisms overlap significantly. Period pain (dysmenorrhea) is primarily driven by prostaglandin-induced uterine smooth muscle contraction, while PCOS pelvic pain has additional drivers: ovarian cyst tension, possible endometriosis co-occurrence (present in 30% of PCOS patients), chronic pelvic floor hypertonicity from ongoing pain, and central sensitization from chronic pelvic pain. CBD addresses all of these through overlapping mechanisms (CB1/CB2 in pelvic tissue, TRPV1 desensitization, central sensitization modulation via 5-HT1A). The practical difference: PCOS pelvic pain may be more chronic and less predictably cyclical than primary dysmenorrhea, making the consistent daily morning oil protocol more important than the cyclically timed approach that works for primary period pain. For the full period pain guide, seeCBD for Period Pain.

 

What dose of CBD for PCOS?

20–25mg of nano-optimizedPureCraft CBD Oil sublingually each morning before coffee is the foundation — consistent daily dosing for HPA modulation, systemic anti-inflammatory CB2 effects, and anxiolytic support. For significant anxiety comorbidity: consider 25–30mg. For pelvic pain management: an additional 10–15mg before anticipated pain-peak.CBD+CBN Sleep Gummies (1 gummy nightly) for sleep.CBD Topical for acne-affected skin areas. Assess at 6–8 weeks for anxiety and pain benefits; topical acne improvement within 2–4 weeks.

 

Is CBD safe with Metformin for PCOS?

Metformin is primarily renally excreted with minimal hepatic CYP450 metabolism — the CBD-Metformin pharmacokinetic interaction is not expected to be clinically significant. However, both CBD and Metformin have modest blood-glucose-lowering potential, and people with insulin-resistant PCOS using both should monitor blood glucose and inform their prescribing physician. The more meaningful interaction is the blood glucose monitoring requirement, not drug level changes. At standard CBD doses (20–35mg daily), Metformin blood levels are not expected to be meaningfully affected. Physician disclosure is appropriate and allows your care team to monitor your complete supplement picture. SeeCBD and Drug Interactions for the full picture.

 

Can CBD help PCOS-related anxiety and mood?

Yes — this is CBD's most directly evidence-supported PCOS application. PCOS anxiety and depression operate through the same HPA, 5-HT1A, and ECS mechanisms that CBD addresses in general anxiety and depression populations. The 34–57% anxiety prevalence in PCOS reflects a specific neurobiological burden from chronic hormonal stress, cortisol dysregulation, and allopregnanolone fluctuations — all of which CBD's mechanisms address through established pathways. The timeline is the same as for general anxiety: acute anxiolytic effects within 30–60 minutes of sublingual dosing; cumulative HPA and 5-HT1A sensitization effects at 4–8 weeks of consistent daily use. For the full anxiety mechanism guide, see the dedicated CBD for Anxiety Pillar.

 

CBD and PCOS fertility — what do we know?

The honest answer is: not enough to make a recommendation. The ECS plays a role in ovarian follicle development and oocyte maturation, and PCOS patients show reduced anandamide in follicular fluid. CBD's FAAH inhibition could theoretically improve follicular ECS tone. However, CBD's effects on the HPO axis during fertility-critical periods — oocyte maturation, fertilization, implantation — have not been adequately studied in humans. The preclinical data is mixed (some protective, some potentially disruptive effects depending on timing and dose). Until adequate human fertility safety data exists, CBD should be used with reproductive endocrinologist guidance for people actively trying to conceive, and avoided during fertility treatment and pregnancy.

 

CBD vs spearmint tea for PCOS?

They are not competing — they address different PCOS mechanisms. Spearmint tea's two small RCTs show modest free androgen reduction that CBD cannot replicate (CBD does not reduce androgens meaningfully). CBD's strength is in anxiety, HPA modulation, pain, inflammation, sleep, and acne — dimensions that spearmint tea doesn't address. For PCOS patients looking for natural approaches, the combination of daily spearmint tea (for the limited but specific anti-androgenic data) alongside CBD (for anxiety, sleep, pain, and acne) is more comprehensive than either alone. No interaction is expected between spearmint and CBD.

 

The Bottom Line: CBD for PCOS

PCOS is a multi-system condition — and CBD's multi-mechanism profile means it has more genuine applications here than most single-symptom supplements. The critical framing: CBD addresses the anxiety, pain, inflammation, sleep, and skin dimensions of PCOS through well-characterized mechanisms. It does not regulate hormones, reduce androgens, restore ovulatory regularity, or treat the underlying metabolic dysregulation of PCOS.

 

For people with PCOS whose most impairing symptoms are anxiety, pelvic pain, and sleep disruption — a common clinical picture — CBD's evidence base is most directly applicable and the potential for meaningful quality-of-life improvement is real. For people whose primary PCOS concerns are hirsutism, fertility, or metabolic management, physician-directed treatment remains the appropriate primary approach, with CBD as a potential complement for the symptom dimensions it does address.

 

The PCOS protocol:PureCraft Nano CBD Oil 1000mg — 20–25mg sublingually each morning before coffee.CBD+CBN Sleep Gummies — 1 gummy nightly.CBD Topical — for acne-affected skin 1–2x daily. Disclose to your PCOS care team. Zero THC, nano-optimized,batch-tested COA. Assess at 6–8 weeks.

 

Important Medical Notice  |  This article is for informational and educational purposes only. PCOS requires physician-directed management. CBD is a supplement that may support symptom management — it does not regulate hormones, reduce androgens meaningfully, or improve fertility. CBD inhibits CYP3A4 and CYP2C8 enzymes relevant to several PCOS medications — disclose to your physician before combining. Do not use CBD as a substitute for Metformin, oral contraceptives, or other physician-prescribed PCOS treatments. PureCraft CBD products are not intended to diagnose, treat, cure, or prevent any disease. Individual results may vary.

 

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